| Identification | Back Directory | [Name]
N-(Mal-PEG6)-N-bis(PEG7-TCO) | [CAS]
2093152-84-0 | [Synonyms]
N-(Mal-PEG6)-N-bis(PEG7-TCO)
5,8,11,14,21,24,27,33,36,39,46,49,52,55-Tetradecaoxa-2,18,30,42,58-pentaazanonapentacontanedioic acid, 30-[25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,23-dioxo-4,7,10,13,16,19-hexaoxa-22-azapentacos-1-yl]-17,43-dioxo-, 1,59-di-4-cycloocten-1-yl ester | [Molecular Formula]
C78H137N7O30 | [MDL Number]
MFCD30723286 | [MOL File]
2093152-84-0.mol | [Molecular Weight]
1652.95 |
| Chemical Properties | Back Directory | [Boiling point ]
1355.0±65.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
11.65±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry branched PEG linker with maleimide and TCO moieties. The maleimide can react with thiol groups between pH 6.5 to 7.5. TCO can be used to label antibodies and proteins via fast Click Chemistry reactions. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media. | [Uses]
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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