| Identification | Back Directory | [Name]
Benzo[a]phenazin-5-ol | [CAS]
2089-82-9 | [Synonyms]
sAJM589 >=98% (HPLC)
Benzo[a]phenazin-5-ol | [Molecular Formula]
C16H10N2O | [MDL Number]
MFCD00437759 | [MOL File]
2089-82-9.mol | [Molecular Weight]
246.26 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (20.30 mM) | [Boiling point ]
522.2±15.0 °C(Predicted) | [density ]
1.393±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.15±0.30(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC50 of 1.8 μM[1]. | [Biological Activity]
sAJM589 is a Myc inhibitor th at disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Mycleading to proteasome-mediated degradation. | [storage]
Store at -20°C | [References]
[1] Choi SH, et al. Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule. ACS Chem Biol. 2017 Nov 17;12(11):2715-2719. DOI:10.1021/acschembio.7b00799 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
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13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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