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ChemicalBook--->CAS DataBase List--->2086689-04-3

2086689-04-3

2086689-04-3 Structure

2086689-04-3 Structure
IdentificationBack Directory
[Name]

N-(Azido-PEG2)-N-Fluorescein-PEG3-acid
[CAS]

2086689-04-3
[Synonyms]

PUN 89043
N-(Azido-PEG2)-N-Fluorescein-PEG3-acid
[Molecular Formula]

C36H41N5O12S
[MDL Number]

MFCD30723265
[MOL File]

2086689-04-3.mol
[Molecular Weight]

767.81
Hazard InformationBack Directory
[Description]

N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a fluorescein dye linker containing a terminal azide group and a terminal carboxylic acid. The azide group enables PEGylation via Click Chemistry. The terminal carboxylic acid can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
[Uses]

N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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