| Identification | Back Directory | [Name]
IWP-O1 | [CAS]
2074607-48-8 | [Synonyms]
IWP-O1
IWO-O1
IWP-O1(17)
IWP-O1 >=98% (HPLC)
1H-1,2,3-Triazole-1-acetamide, 5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl)- | [Molecular Formula]
C26H20N6O | [MOL File]
2074607-48-8.mol | [Molecular Weight]
432.48 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO : 125 mg/mL (289.03 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells[1]. | [Biological Activity]
IWP-O1 is a porcn inhibitor with an EC50 of 80 pM in a Wnt signaling reporter assay in cultured cells. It can effectively inhibit the phosphorylation of Dvl2/3 in Hela cells. | [in vitro]
IWP-O1 has good metabolic stability. | [target]
| Target | Value | porcn
(Cell-based assay) | 80 pM(EC50) |
| [storage]
4°C, protect from light | [References]
[1] You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. DOI:10.1016/j.bmcl.2016.11.012 |
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