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ChemicalBook--->CAS DataBase List--->2070014-98-9

2070014-98-9

2070014-98-9 Structure

2070014-98-9 Structure
IdentificationBack Directory
[Name]

IFN alpha-IFNAR-IN-1 (hydrochloride)
[CAS]

2070014-98-9
[Synonyms]

IFN alpha-IFR-IN-1 hydrochloride
IFN-α-IFNAR-IN-1 (hydrochloride)
IFN alpha-IFNAR-IN-1 (hydrochloride)
IFN alpha-IFNAR inhibitor 1 hydrochloride
[Molecular Formula]

C??H??ClNS
[MDL Number]

MFCD29472229
[MOL File]

2070014-98-9.mol
[Molecular Weight]

315.86
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 125 mg/mL (395.74 mM)
[form ]

A crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM)[1].
[References]

[1] Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61. DOI:10.1002/anie.201105901
Spectrum DetailBack Directory
[Spectrum Detail]

IFN alpha-IFNAR-IN-1 (hydrochloride)(2070014-98-9)1HNMR
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