| Identification | Back Directory | [Name]
Mcl1-IN-12 | [CAS]
2042211-12-9 | [Synonyms]
Mcl1-IN-12
Benzamide, N-[4-[[[[3-nitro-4-[[2-(phenylthio)ethyl]amino]phenyl]sulfonyl]amino]carbonyl]phenyl]-4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]- | [Molecular Formula]
C45H46N4O6S2 | [MDL Number]
MFCD32174236 | [MOL File]
2042211-12-9.mol | [Molecular Weight]
803 |
| Hazard Information | Back Directory | [Uses]
Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively. Anti-tumor activity[1]. | [References]
[1] Wang M, et al. Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5207-5211. DOI:10.1016/j.bmcl.2016.09.061 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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