| Identification | Back Directory | [Name]
6-Boc-2-oxo-6-aza-spiro[3.4]octane | [CAS]
203661-71-6 | [Synonyms]
6-Boc-2-oxo-6-aza-spiro[3...
6-Boc-6-azaspiro[3.4]octan-2-one
6-Boc-2-oxo-6-aza-spiro[3.4]octane
6-N-Boc-2-oxo-6-aza-spiro[3.4]octane
6-Azaspiro[3.4]octan-2-one,N-BOCprotected
benzyl 2-oxo-6-azaspiro[3.4]octane-6-carboxylate
tert-Butyl 2-oxo-7-azaspiro[3.4]octane-7-carboxylate
2-Oxo-6-aza-spiro[3.4]octane-6-carboxylic acid tert-butyl-ester
2-oxo-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester
2-Oxo-6-aza-spiro[3.4]octane-6-carboxylic acid tert-butyl-ester - X7188
6-Azaspiro[3.4]octane-6-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C12H19NO3 | [MDL Number]
MFCD17016202 | [MOL File]
203661-71-6.mol | [Molecular Weight]
225.284 |
| Chemical Properties | Back Directory | [Boiling point ]
331.8±35.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
-0.80±0.20(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C12H19NO3/c1-11(2,3)16-10(15)13-5-4-12(8-13)6-9(14)7-12/h4-8H2,1-3H3 | [InChIKey]
WQPZESPYNGQLQA-UHFFFAOYSA-N | [SMILES]
C1C2(CCN(C(OC(C)(C)C)=O)C2)CC1=O |
| Hazard Information | Back Directory | [Synthesis]
1.21 mol) and zinc powder (Zn, 79.1 g, 1.21 mol). The reaction mixture was stirred at room temperature for 8 hours. After completion of the reaction, the mixture was treated with distilled water (H2O) and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel, eluent: petroleum ether to 25% ethyl acetate in petroleum ether solution) to afford the target product R-5 (19 g, 69% yield). | [References]
[1] Patent: US2014/45813, 2014, A1. Location in patent: Paragraph 0113
[2] Patent: US2014/275014, 2014, A1. Location in patent: Paragraph 0128; 0129; 0132
[3] Patent: WO2015/116485, 2015, A1. Location in patent: Page/Page column 24; 25 |
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