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ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’[1][2][3][4]. | [in vivo]
ODN 1826 (18 nM, subcutaneous injection, 3 times a week for 7 weeks) increases aortic atherosclerotic plaque size in a mouse model of chronic vascular injury [1].
ODN 1826 (0.05 mg, intraperitoneally injected , 1, 3, 5, 8, 11, 13 days) has a strong anti-tumor growth effect[3].
Animal Model: | Chronic vascular injury mouse models[1] | Dosage: | 18 nM CPG ODN | Administration: | s.c, three times a week for 7 weeks | Result: | Increased in aortic atherosclerotic plaque size compared to vehicle. |
Animal Model: | Lewis Lung Cancer Murine Tumor Model[3] | Dosage: | 0.05 mg (1, 3, 5, 8, 11, 13 days) | Administration: | Intraperitoneal injection (i.p.) | Result: | Delayed tumor growth,decreased tumor weight and increased the apoptosis of tumor cells. |
| [IC 50]
TLR9 | [References]
[1] Krogmann AO, et al. Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice. PLoS One. 2016 Jan 11;11(1):e0146326. DOI:10.1371/journal.pone.0146326 [2] Utaisincharoen P, et al. CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7). Clin Exp Immunol. 2002 Jun;128(3):467-73. DOI:10.1046/j.1365-2249.2002.01866.x [3] Yuan S, et al. CpG oligodeoxynucleotide 1826 enhances the Lewis lung cancer response to radiotherapy in murine tumor. Cancer Biother Radiopharm. 2011 Apr;26(2):203-8. DOI:10.1089/cbr.2010.0871 [4] Zhang X, et al. The toll-like receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhage. Shock. 2012 Aug;38(2):146-52. DOI:10.1097/SHK.0b013e31825ce0de |
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