| Identification | Back Directory | [Name]
isodiospyrin | [CAS]
20175-84-2 | [Synonyms]
Isoquinone
isodiospyrin
Isodiospirin
[1,2'-BINAPHTHALENE]-5,5',8,8'
1,2’-Binaphthalene-5,5’,8,8’-tet
[1,2’-Binaphtalene]-5,5’,8,8’-tet
(-)-1',4-Dihydroxy-2,3'-dimethyl-(1,2'-binaphthalene)-5,5',8,8'-tetrone
[1,2'-Binaphthalene]-5,5',8,8'-tetrone,1',4-dihydroxy-2,3'-dimethyl-, (1R)-
5-hydroxy-6-(4-hydroxy-2-methyl-5,8-dioxonaphthalen-1-yl)-7-methylnaphthalene-1,4-dione
IsodiospyrinQ: What is
Isodiospyrin Q: What is the CAS Number of
Isodiospyrin Q: What is the storage condition of
Isodiospyrin | [Molecular Formula]
C22H14O6 | [MOL File]
20175-84-2.mol | [Molecular Weight]
374.34 |
| Chemical Properties | Back Directory | [Melting point ]
233 °C | [Boiling point ]
712.0±60.0 °C(Predicted) | [density ]
1.495±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.66±0.20(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3]. | [Definition]
ChEBI:Isodiospyrin is a member of biphenyls. | [IC 50]
Topoisomerase I | [References]
[1] Chun-Yuan Ting, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol. 2003 Nov 15;66(10):1981-91. DOI:10.1016/j.bcp.2003.07.003
[2] B A Adeniyi, et al. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria (Gurke) (Ebenaceae). Phytother Res. 2000 Mar;14(2):112-7. DOI:10.1002/(sici)1099-1573(200003)14:2<112::aid-ptr488>3.0.co;2-t
[3] Xiaoning Wang, et al. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. Chem Biodivers. 2011 Dec;8(12):2331-40. DOI:10.1002/cbdv.201000310 |
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