| Identification | Back Directory | [Name]
HMCEF | [CAS]
2002363-68-8 | [Synonyms]
HMCEF
L-Phenylalanine, N-[2-[3-(hydroxymethyl)-9H-pyrido[3,4-b]indol-1-yl]ethyl]- | [Molecular Formula]
C23H23N3O3 | [MOL File]
2002363-68-8.mol | [Molecular Weight]
389.45 |
| Hazard Information | Back Directory | [Uses]
HMCEF is an orally active P-selectin inhibitor and inhibits P-selectin expression. HMCEF blocks the interaction between P-selectin and natural ligands, such as PSGL-1. HMCEF inhibits thrombosis and inflammation in mice[1]. | [References]
[1] Wu J, et al. A novel lead of P-selectin inhibitor: Discovery, synthesis, bioassays and action mechanism. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4631-4636. DOI:10.1016/j.bmcl.2016.08.061 |
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