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ChemicalBook--->CAS DataBase List--->1985638-39-8

1985638-39-8

1985638-39-8 Structure

1985638-39-8 Structure
IdentificationBack Directory
[Name]

Marstacimab
[CAS]

1985638-39-8
[Synonyms]

Marstacimab
Research Grade Marstacimab(DHC82803)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia[1][2].
[in vivo]

Marstacimab (0.5 mg/kg; i.v., once) does not affect the blood flow situation in mouse acute bleeding models[2].

Animal Model:Acute bleeding hemophilia A mouse models[2]
Dosage:0.5 mg/kg
Administration:Intravenous injection, 0.5 mg/kg, once, before tail clip
Result:Showed no effect on the blood loss compared with control mice, but significantly reduced the blood loss with the combination of aPCC 200 U/kg.
[References]

[1] Patel-Hett S, et al. Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas. Haemophilia. 2019 Sep;25(5):797-806. DOI:10.1111/hae.13820
[2] Pittman DD, et al. Hemostatic efficacy of marstacimab alone or in combination with bypassing agents in hemophilia plasmas and a mouse bleeding model. Res Pract Thromb Haemost. 2022 Mar 16;6(2):e12679. DOI:10.1002/rth2.12679
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