| Identification | Back Directory | [Name]
GB 1107) | [CAS]
1978336-61-6 | [Synonyms]
GB 1107)
GB1107
(GB-1107
(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol | [Molecular Formula]
C20H16Cl2F3N3O4S | [MDL Number]
MFCD31813764 | [MOL File]
1978336-61-6.mol | [Molecular Weight]
522.32 |
| Chemical Properties | Back Directory | [Boiling point ]
740.1±70.0 °C(Predicted) | [density ]
1.73±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,protect from light | [solubility ]
DMSO:50.0(Max Conc. mg/mL);95.73(Max Conc. mM) | [form ]
Solid | [pka]
12.48±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
CSGJIUAIYDKFPC-XOZWYLPJNA-N | [SMILES]
O[C@H]1[C@H](O[C@H](CO)[C@H](O)[C@@H]1N1N=NC(C2C=C(F)C(F)=C(F)C=2)=C1)SC1C=CC(Cl)=C(Cl)C=1 |&1:1,2,4,7,9,r| |
| Hazard Information | Back Directory | [Description]
GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade. | [Uses]
GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1]. | [in vivo]
Oral administration of a novel small molecule galectin-3 inhibitor GB1107 reduced human and mouse lung adenocarcinoma growth and blocked metastasis in the syngeneic model. Treatment with GB1107 increased tumor M1 macrophage polarization and CD8+ T-cell infiltration. Moreover, GB1107 potentiated the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFNγ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules._x000D_
_x000D_
Reference: Cancer Res. 2019 Apr 1;79(7):1480-1492. https://pubmed.ncbi.nlm.nih.gov/30674531/ | [target]
GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. | [IC 50]
Galectin-3 | [storage]
Store at -20°C,protect from light | [References]
[1] Vuong L, et al. An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. Cancer Res. 2019 Jan 23. pii: canres.2244.2018. DOI:10.1158/0008-5472.CAN-18-2244 |
|
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|