| Identification | Back Directory | [Name]
RPR107393 free base | [CAS]
197576-78-6 | [Synonyms]
RPR107393 free base
1-Azabicyclo[2.2.2]octan-3-ol, 3-[4-(6-quinolinyl)phenyl]- | [Molecular Formula]
C22H22N2O | [MDL Number]
MFCD30533342 | [MOL File]
197576-78-6.mol | [Molecular Weight]
330.42 |
| Chemical Properties | Back Directory | [Boiling point ]
523.5±50.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
13.75±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
RPR107393, is a selective squalene synthase inhibitor, which inhibits rat liver microsomal squalene synthase with an IC50 of 0.8±0.2 nM. | [in vivo]
One hour after RPR107393 (10 mg/kg p.o.), Cholesterol biosynthesis is reduced by 92% with an approximate ED50 value of 5 mg/kg. Six hours after RPR107393 (10 mg/kg p.o.) administration, Cholesterol biosynthesis is reduced by 74% (the time for 50% inhibition is ~7 hr). An 82% inhibition of hepatic Cholesterol biosynthesis is observed 10 hr after RPR107393 (25 mg/kg p.o.), but the effect is no longer apparent at 21 hr. Inhibition of Cholesterol biosynthesis by Zaragozic acid or RPR107393 is associated with an accumulation of radiolabeled diacid products in the liver. RPR107393 is a potent Cholesterol-lowering agent in rats. RPR107393 (30 mg/kg p.o. b.i.d.) lowers serum Cholesterol by 35% after 2 days and by nearly 50% after 3 days of treatment[1]. | [storage]
Store at -20°C |
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