| Identification | Back Directory | [Name]
(5-Ethylisoxazol-3-yl)amine | [CAS]
19754-80-4 | [Synonyms]
3-Amino-5-ethylisoxazole
3-Isoxazolamine, 5-ethyl-
5-ethyl-1,2-oxazol-3-amine
(5-Ethylisoxazol-3-yl)amine | [Molecular Formula]
C5H8N2O | [MDL Number]
MFCD00955701 | [MOL File]
19754-80-4.mol | [Molecular Weight]
112.13 |
| Chemical Properties | Back Directory | [Melting point ]
71-72℃ | [Boiling point ]
243.8±20.0 °C(Predicted) | [density ]
1.115±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.41±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-amino-5-ethylisoxazole from 3-oxovaleronitrile: A portion of the resulting product (0.6 g) was taken and mixed with hydrazine hydrate (0.28 ml) and ethanol (45 ml), and the reaction was heated for 12 hr at 70 °C. After completion of the reaction, the solvent was removed by evaporation and the resulting residue was purified by silica gel column chromatography, using a solvent mixture of dichloromethane and methanol (19:1, v/v) as eluent. The target product 3-amino-5-ethylisoxazole was finally obtained in 51% yield. The product was characterized by 1H NMR (solvent DMSO-d6): δ 1.04 (t, 3H), 2.41 (q, 2H), 4.4 (br s, 2H). | [References]
[1] Patent: US2009/76075, 2009, A1. Location in patent: Page/Page column 38
[2] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 1189; 1190 |
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