| Identification | Back Directory | [Name]
EMD 270179 | [CAS]
197172-76-2 | [Synonyms]
EMD 270179
Cyclopeptide-5
RonaCare Cyclopeptide 5
Cyclotetrapeptide-24 aminocyclohexane carboxylate
Cyclopeptide-5/CycloTetrapeptide-24 AminocyclohexaneCarboxylate
Cyclo(1-aminocyclohexanecarbonyl-L-arginylglycyl-L-α-aspartyl-D-phenylalanyl)
Cyclo(1-aminocyclohexanecarbonyl-L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl) | [Molecular Formula]
C28H40N8O7 | [MOL File]
197172-76-2.mol | [Molecular Weight]
600.67 |
| Hazard Information | Back Directory | [Uses]
Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects[1][2]. | [References]
[1] M Abo-Ghalia, et al. Synthesis and investigation of a new cyclo (Nalpha-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity. Amino Acids. 2004 Jun;26(3):283-9. DOI:10.1007/s00726-003-0042-8
[2] Eileen M Finnegan, et al. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1038-45. DOI:10.1152/ajpheart.01054.2006 |
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