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ChemicalBook--->CAS DataBase List--->1957278-93-1

1957278-93-1

1957278-93-1 Structure

1957278-93-1 Structure
IdentificationBack Directory
[Name]

2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)-
[CAS]

1957278-93-1
[Synonyms]

GLPG1972
S201086)
Aldumastat
Aldumastat (GLPG1972
5(R)-Cyclopropyl-5-{3-[4-(3,5-difluoro-phenyl)-3(R)-methyl-piperazin-1-yl]-3-oxo-propyl}-imidazolidine-2,4-dione
2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)-
[Molecular Formula]

C20H24F2N4O3
[MDL Number]

MFCD31690991
[MOL File]

1957278-93-1.mol
[Molecular Weight]

406.43
Chemical PropertiesBack Directory
[density ]

1.336±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 100 mg/mL (246.04 mM; Need ultrasonic)
[form ]

Solid
[pka]

8.79±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard InformationBack Directory
[Uses]

Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research[1].
[in vivo]

GLPG1972 (oral gavage; 5 mg/kg; single dose) displays a favorable PK profile in mice, rats, and dogs. The oral availability (F%) for mice, rats, and dogs are 25%, 58% and 97%, respectively[1].

[IC 50]

ADAMTS-5: 19 nM (IC50); ADAMTS-4: 156 nM (IC50); MMP-2: 1158 nM (IC50); MMP-14: >3198 nM (IC50)
[storage]

Store at -20°C
[References]

[1] Franck Brebion, et al. Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis. J Med Chem. 2021 Mar 25;64(6):2937-2952. DOI:10.1021/acs.jmedchem.0c02008
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