| Identification | Back Directory | [Name]
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- | [CAS]
193957-88-9 | [Synonyms]
Triptohypol C
Dihydrocelastrol
DHCE. (-)-Triptohypol C
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- | [Molecular Formula]
C29H40O4 | [MOL File]
193957-88-9.mol | [Molecular Weight]
452.64 |
| Chemical Properties | Back Directory | [Boiling point ]
596.0±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.79±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1]. | [Definition]
ChEBI: Triptohypol C is a pentacyclic triterpenoid with formula C29H40O4, originally isolated from the root bark of Tripterygium regelii. It has a role as a plant metabolite and an apoptosis inducer. It is a pentacyclic triterpenoid, a monocarboxylic acid and a member of benzenediols. | [in vivo]
Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%). | Animal Model: | Zebrafish[1] | | Dosage: | 0.5?μM, 1?μM and 1.25?μM | | Administration: | 72 h | | Result: | Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25?μM for 24?h or at a concentration of 0.5?μM for 72?h. |
| [IC 50]
Nur77/NR4A1 | [References]
[1] Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187. DOI:10.1016/j.ejmech.2019.05.009 |
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