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ChemicalBook--->CAS DataBase List--->193807-60-2

193807-60-2

193807-60-2 Structure

193807-60-2 Structure
IdentificationBack Directory
[Name]

MMP-9 Inhibitor II
[CAS]

193807-60-2
[Synonyms]

Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II
Benzenepropanamide, α-[([1,1'-biphenyl]-4-ylsulfonyl)amino]-N-hydroxy-, (αR)-
MMP-2/MMP-9 INHIBITOR II;MATRIX METALLOPROTEINASE-2/MATRIX METALLOPROTEINASE-9 INHIBITOR II
[Molecular Formula]

C21H20N2O4S
[MDL Number]

MFCD02683958
[MOL File]

193807-60-2.mol
[Molecular Weight]

396.46
Chemical PropertiesBack Directory
[Melting point ]

169-170 °C
[density ]

1.309±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 100 mg/ml; Methanol: 25 mg/ml
[form ]

A solid
[pka]

9.03±0.40(Predicted)
[color ]

off-white
Hazard InformationBack Directory
[Uses]

MMP-2/MMP-9 Inhibitor II is a potent inhibitor of MMP-2 and MMP-9.
[Biological Activity]

Cell permeable: no''Primary Target
MMP-2''Product does not compete with ATP.''Reversible: no''Target IC50: 17 nM30 nM against MMP-2and MMP-9respectively
[in vivo]

Daily oral administration of 200 mg/kg BPHA in mice results in potent inhibition of tumor-induced angiogenesis, primary tumor growth, and liver metastasis. The growth inhibition activity of BPHA is 48% and 45% in a B16-BL6 melanoma and F2 hemangio-endothelioma model, respectively[1].

[IC 50]

MMP-2: 12 nM (IC50); MMP-9: 16 nM (IC50); MMP-14: 17 nM (IC50); MMP-1: 974 nM (IC50); MMP-3: >1000 nM (IC50); MMP-7: 795 nM (IC50)
[storage]

Store at -20°C
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