| Identification | Back Directory | [Name]
2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER | [CAS]
19350-66-4 | [Synonyms]
AV-153 free base
3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid
3,4,5-Pyridinetricarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester | [Molecular Formula]
C14H19NO6 | [MDL Number]
MFCD00417306 | [MOL File]
19350-66-4.mol | [Molecular Weight]
297.3 |
| Chemical Properties | Back Directory | [Boiling point ]
450.5±45.0 °C(Predicted) | [density ]
1.230±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO: 250 mg/mL (840.90 mM) | [form ]
Solid | [pka]
1.47±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity[1][2][3]. | [References]
[1] Nadezhda I Ryabokon, et al. A 1,4-dihydropyridine Derivative Reduces DNA Damage and Stimulates DNA Repair in Human Cells in Vitro. Mutat Res. 2005 Nov 10;587(1-2):52-8. DOI:10.1016/j.mrgentox.2005.07.009
[2] E Buraka, et al. DNA-binding Studies of AV-153, an Antimutagenic and DNA Repair-Stimulating Derivative of 1,4-dihydropiridine. Chem Biol Interact. 2014 Sep 5;220:200-7. DOI:10.1016/j.cbi.2014.06.027
[3] Lidija Milkovic, et al. Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-Like Cells In Vitro. Antioxidants (Basel). 2018 Sep 19;7(9):123. DOI:10.1016/j.cbi.2014.06.027 |
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