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ChemicalBook--->CAS DataBase List--->1917350-09-4

1917350-09-4

1917350-09-4 Structure

1917350-09-4 Structure
IdentificationBack Directory
[Name]

L-Leucine, N-[2-oxo-2-(2-phenyl-1H-indol-3-yl)acetyl]-L-phenylalanyl-, methyl ester
[CAS]

1917350-09-4
[Synonyms]

MDM2-p53-IN-16
L-Leucine, N-[2-oxo-2-(2-phenyl-1H-indol-3-yl)acetyl]-L-phenylalanyl-, methyl ester
[Molecular Formula]

C32H33N3O5
[MOL File]

1917350-09-4.mol
[Molecular Weight]

539.62
Chemical PropertiesBack Directory
[density ]

1.223±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

10.50±0.46(Predicted)
[color ]

Light green to green
Hazard InformationBack Directory
[Uses]

MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research[1].
[References]

[1] Daniele S, et al. Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas. J Med Chem. 2016 May 26;59(10):4526-38. DOI:10.1021/acs.jmedchem.5b01767
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