| Identification | Back Directory | [Name]
AC-WEHD-AMC | [CAS]
189275-74-9 | [Synonyms]
AC-WEHD-AMC
AC-WEHD-MCA
AC-WEHD-AMC USP/EP/BP
AC-TRP-GLU-HIS-ASP-AMC
AC-TRP-GLU-HIS-ASP-MCA
CASPASE-1 SUBSTRATE (FLUOROGENIC)
CASPASE-1 SUBSTRATE X, FLUOROGENIC
CASPASE-5 SUBSTRATE III, FLUOROGENIC
CASPASE 1 (ICE) SUBSTRATE 3M, FLUOROGENIC
AC-TRP-GLU-HIS-ASP-7-AMINO-4-METHYLCOUMARIN
N-ACETYL-TRP-GLU-HIS-ASP 7-AMIDO-4-METHYLCOUMARIN
N-ACETYL-TRP-GLU-HIS-ASP-7-AMINO-4-METHYLCOUMARIN AMC
ACETYL-L-TRYPTOPHYL-L-GLUTAMYL-L-HISTIDYL-L-ASPARTIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE)
N-Acetyl-L-tryptophyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine | [EINECS(EC#)]
275-771-1 | [Molecular Formula]
C38H40N8O11 | [MDL Number]
MFCD01318829 | [MOL File]
189275-74-9.mol | [Molecular Weight]
784.77 |
| Chemical Properties | Back Directory | [Boiling point ]
1399.8±65.0 °C(Predicted) | [density ]
1.465±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO: 5mg/mL | [form ]
powder | [pka]
4.07±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1[1]. | [Biological Activity]
Cell permeable: no''Product does not compete with ATP.''Reversible: no | [References]
[1] Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. DOI:10.1016/j.chembiol.2010.07.011 |
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