| Identification | Back Directory | [Name]
MI-1481 | [CAS]
1887178-64-4 | [Synonyms]
MI-1481
1H-Indole-2-carbonitrile, 4-methyl-1-[[(2S)-5-oxo-2-morpholinyl]methyl]-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]- | [Molecular Formula]
C29H30F3N7O2S | [MOL File]
1887178-64-4.mol | [Molecular Weight]
597.65 |
| Hazard Information | Back Directory | [Uses]
MI-1481 is a highly potent inhibitor of the Menin-MLL1 interaction with IC50 of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression[1]. | [References]
[1] Borkin D, et.al. Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. J Med Chem. 2018 Jun 14;61(11):4832-4850. DOI:10.1021/acs.jmedchem.8b00071 |
|
|