| Identification | Back Directory | [Name]
(E)-6-(3-morpholinopropyl)-2-(thieno[3,2-c]pyridin-6-yl)-4H-chromen-4-one oxime | [CAS]
1883329-51-8 | [Synonyms]
(E)-6-(3-morpholinopropyl)-2-(thieno[3,2-c]pyridin-6-yl)-4H-chromen-4-one oxime | [Molecular Formula]
C23H23N3O3S | [MDL Number]
MFCD30481305 | [MOL File]
1883329-51-8.mol | [Molecular Weight]
421.51 |
| Chemical Properties | Back Directory | [Boiling point ]
646.9±55.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5.2 mg/mL (12.34 mM and warming) | [pka]
10.92±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1]. | [IC 50]
mGlu4: 79 nM (EC50) | [References]
[1] Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. DOI:10.1021/acs.jmedchem.7b00991
[2] Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423. DOI:10.1080/17460441.2018.1443076 |
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