| Identification | Back Directory | [Name]
JAK1/TYK2-IN-1 | [CAS]
1883300-48-8 | [Synonyms]
JAK1/TYK2-IN-1
Cyclopropanecarboxamide, 2,2-difluoro-N-[(1S,5R,6R)-3-[5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-6-methyl-3-azabicyclo[3.1.0]hex-1-yl]-, (1S)- | [Molecular Formula]
C18H20F3N7O | [MOL File]
1883300-48-8.mol | [Molecular Weight]
407.39 |
| Hazard Information | Back Directory | [Uses]
JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively). | [References]
[1] Fensome A, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28(10):115481. DOI:10.1016/j.bmc.2020.115481 |
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