| Identification | Back Directory | [Name]
Massoniaside B | [CAS]
188300-19-8 | [Synonyms]
Massoniaside B
Massonianoside B
α-L-Mannopyranoside, 4-[(2S,3R)-2,3-dihydro-7-hydroxy-3-(hydroxymethyl)-5-(3-hydroxypropyl)-2-benzofuranyl]-2-methoxyphenyl 6-deoxy | [Molecular Formula]
C25H32O10 | [MOL File]
188300-19-8.mol | [Molecular Weight]
492.52 |
| Chemical Properties | Back Directory | [Boiling point ]
708.9±60.0 °C(Predicted) | [density ]
1.406±0.06 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
9.91±0.60(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Massonianoside B can be used for pharmaceutical compositions as active ingredient to prevent and treat mixed lineage leukemia rearranged leukemia. | [Biological Activity]
Massonianoside B is a cell-permeablepotenthighly selectivereversible and SAM-competitive DOT1L (disruptor of 4 telomeric silencing 1-like) inhibitor th at decreases cellular levels of H3K79 methylation and inhibits the MLL fusion target genes HOXA9 and MEIS1 expression. Massonianoside B exhibits anti-leukemic activity. It is metabolically stable in both human and mouse liver microsomes. |
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| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
| Company Name: |
Cool Pharm, Ltd
|
| Tel: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
|