| Identification | Back Directory | [Name]
Propargyl-PEG4-(CH2)3-methyl ester | [Synonyms]
Propargyl-PEG4-CH2-methyl ester
Propargyl-PEG4-(CH2)3-methyl este
Propargyl-PEG4-(CH2)3-methyl ester
5,8,11,14-Tetraoxaheptadec-16-ynoic acid, methyl ester | [MDL Number]
MFCD29079394 | [MOL File]
1872433-63-0.mol |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-(CH2)3-methyl ester consists of a propargyl group and a methyl ester. The propargyl group reacts with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions to form a stable triazole linkage. Under strong basic condition, methyl ester can be hydrolyzed. | [Uses]
Propargyl-PEG4-CH2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2-methyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|