| Identification | Back Directory | [Name]
(ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR770 (667-676) | [CAS]
186142-28-9 | [Synonyms]
SEVNLDAEFR
H-Ser-Glu-Val-Asn
β-Secretase SubstrateⅡ
BETA-SECRETASE SUBSTRATE II
[ASN670, LEU671]AMYLOID-BETA
(ASN670,LEU671)-APP770 (667-676)
A4 PROTEIN PRECURSOR770 (667-676)
SER-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-ARG
H-SER-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-ARG-OH
(ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR 7
(Asn,Leu61)-Amyloid β/A4 Protein Precursor (667-676)
(Asn???,Leu6?1)-Amyloid β/A4 Protein Precursor??? (667-676)
[Asn670,Leu671]-Amyloid β/A4 Protein Precursor770 (667-676)
(ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR770 (667-676)
(Asn670,Leu671)-APP770 (667-676), APP770 (667-676) Swedish Mutation
(ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR770 (667-676) USP/EP/BP
(Asn???,Leu??1)-Amyloid β/A4 Protein Precursor??? (667-676) trifluoroacetate salt
(Asn???,Leu???)-Amyloid β/A4 Protein Precursor??? (667-676) trifluoroacetate salt
(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-676) trifluoroacetate salt
[asn670, leu671]-amyloid β/a4 precursor protein 770 fragment 667-676 trifluoroacetate salt
Asn670, Leu671]-Amyloid beta/A4 Precursor Protein 770 Fragment 667-676 trifluoroacetate salt
Asn670, Leu671]-Amyloid beta/A4 Precursor Protein 770 Fragment 667-676 trifluoroacetate salt >=95% (HPLC), solid
L-Arginine, L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl- | [Molecular Formula]
C50H78N14O19 | [MDL Number]
MFCD02684497 | [MOL File]
186142-28-9.mol | [Molecular Weight]
1179.24 |
| Hazard Information | Back Directory | [Uses]
SEVNLDAEFR is a substrate for BACE1[1]. | [Biochem/physiol Actions]
Substrate for assaying β-secretase activity that corresponds to the "Swedish" Lys-Met/Asn-Leu mutation of the amyloid precursor protein β-secretase cleavage site. | [References]
[1] Machálková M, et al. A label-free MALDI TOF MS-based method for studying the kinetics and inhibitor screening of the Alzheimer's disease drug target β-secretase. Anal Bioanal Chem. 2018 Nov;410(28):7441-7448. DOI:10.1007/s00216-018-1354-6 |
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