| Identification | Back Directory | [Name]
9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester | [CAS]
1853202-95-5 | [Synonyms]
OF-DEG-LIN
50-C2-C18lin2-4tail
9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester
9,12-Octadecadienoic acid (9Z,12Z)-, 1,1',1'',1'''-[(3,6-dioxo-2,5-piperazinediyl)bis(4,1-butanediylnitrilodi-2,1-ethanediyl)] ester | [Molecular Formula]
C92H160N4O10 | [MOL File]
1853202-95-5.mol | [Molecular Weight]
1482.31 |
| Chemical Properties | Back Directory | [Boiling point ]
1190.6±65.0 °C(Predicted) | [density ]
0.968±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
12.86±0.60(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs). | [in vivo]
OF-Deg-Lin (iv, single dose) induces the majority of protein expression in the spleen, labels a certain proportion of B cells in the spleen, while causing minimal translation in other organs in mouse models[2]. | Animal Model: | C57BL/6 mouse models[2] | | Dosage: | 0.75-2.25 mg/kg in form of OF-Deg-Lin mRNA LNPs | | Administration: | iv, single dose | | Result: | Induced 85% of total protein production in the spleen, labeled ca. 7% of the total B cell population in C57BL/6 mice. |
| [References]
[1] Rissanou AN, Karatasos K. Effects of the structure of lipid-based agents in their complexation with a single stranded mRNA fragment: a computational study.?Soft Matter. 2022;18(33):6229-6245. DOI:10.1039/d2sm00403h
[2] Fenton OS, et al., Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes. Adv Mater. 2017 Sep;29(33). DOI:10.1002/adma.201606944 |
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