| Identification | Back Directory | [Name]
2-Chloromethyloxazole | [CAS]
185246-17-7 | [Synonyms]
2-CHLOROMETHYL-OXAZOLE
Lactic Acid Impurity 17
OXAZOLE, 2-(CHLOROMETHYL)-
2-(Chloromethyl)-1,3-oxazole | [Molecular Formula]
C4H4ClNO | [MDL Number]
MFCD04114926 | [MOL File]
185246-17-7.mol | [Molecular Weight]
117.53 |
| Chemical Properties | Back Directory | [Boiling point ]
143.5±23.0 °C(Predicted) | [density ]
1.261±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [form ]
liquid | [pka]
0.37±0.10(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-(chloromethyl)oxazole from 2-hydroxymethyl oxazole: Thionyl chloride (SOCl2, 3.25 mL, 45 mmol) was added slowly and dropwise to a solution of 2-hydroxymethyl oxazole (450 mg, 4.5 mmol) in dichloromethane (DCM, 25 mL) at 0 °C. The reaction mixture was stirred at 0 °C for 1 hour. Subsequently, water (50 mL) and ethyl acetate (EtOAc, 60 mL) were added to the reaction system for extraction. The organic and aqueous phases were separated, and the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 2-(chloromethyl)oxazole as a white solid (200 mg, 1.7 mmol, 37% yield). | [References]
[1] Patent: WO2017/93543, 2017, A2. Location in patent: Page/Page column 101
[2] Patent: WO2007/34144, 2007, A1. Location in patent: Page/Page column 93
[3] Patent: WO2011/35009, 2011, A1. Location in patent: Page/Page column 46 |
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