| Identification | Back Directory | [Name]
LEPTIN (22-56), HUMAN | [CAS]
183598-56-3 | [Synonyms]
LEPTIN (22-56)
OBGRP (22-56), HUMAN
LEPTIN (22-56), HUMAN
LEPTIN FRAGMENT 22-56 HUMAN
Leptin human fragment 22-56
M.W. 3950.50 C171H298N50O56
Obese gene peptide fragment 22-56
OBESE GENE PEPTIDE (22-56) (HUMAN)
VPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQK
Leptin (22-56) (huMan)
Obese Gene Peptide (22-56) (huMan)
VAL-PRO-ILE-GLN-LYS-VAL-GLN-ASP-ASP-THR-LYS-THR-LEU-ILE-LYS-THR-ILE-VAL-THR-ARG-ILE-ASN-ASP-ILE-SER-HIS-THR-GLN-SER-VAL-SER-SER-LYS-GLN-LYS
H-VAL-PRO-ILE-GLN-LYS-VAL-GLN-ASP-ASP-THR-LYS-THR-LEU-ILE-LYS-THR-ILE-VAL-THR-ARG-ILE-ASN-ASP-ILE-SER-HIS-THR-GLN-SER-VAL-SER-SER-LYS-GLN-LYS-OH
VAL-PRO-ILE-GLN-LYS-VAL-GLN-ASP-ASP-THR-LYS-THR-LEU-ILE-LYS-THR-ILE-VAL-THR-ARG-ILE-ASN-ASP-ILE-SER-HIS-THR-GLN-SER-VAL-SER-SER-LYS-GLN-LYS: VPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQK | [Molecular Formula]
C171H298N50O56 | [MDL Number]
MFCD00802382 |
| Chemical Properties | Back Directory | [storage temp. ]
-15°C | [form ]
Solid | [color ]
White to off-white | [Sequence]
H-Val-Pro-Ile-Gln-Lys-Val-Gln-Asp-Asp-Thr-Lys-Thr-Leu-Ile-Lys-Thr-Ile-Val-Thr-Arg-Ile-Asn-Asp-Ile-Ser-His-Thr-Gln-Ser-Val-Ser-Ser-Lys-Gln-Lys-OH |
| Hazard Information | Back Directory | [Uses]
Leptin (22-56), human is the fragment of leptin, mediated via several isoforms of receptors (Ob-Rs). | [Biological Activity]
Leptin (22-56), human is a polypeptide fragment of leptin that acts through various isoforms of Ob-Rs. | [in vitro]
Leptin (22-56), human is the fragment of leptin, inhibits corticosterone production, but shows no effect on the proliferation of cultured adrenocortical cells. It may be responsible for the direct inhibitory effect on secretion and growth of leptin on cultured rat adrenocortical cells. It inhibits food intake, and may favour erythropoiesis. | [References]
[1] Malendowicz LK, et al. Effects of leptin and leptin fragments on corticosterone secretion and growth of cultured rat adrenocortical cells. Int J Mol Med. 2004 Nov;14(5):873-7. PMID:15492859
[2] Stamatiadis DN, et al. Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis. Clin Endocrinol (Oxf). 2004 Apr;60(4):434-41. DOI:10.1111/j.1365-2265.2004.01999.x |
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