| Identification | Back Directory | [Name]
7-Chloro-furo[3,2-b]pyrid... | [CAS]
182691-75-4 | [Synonyms]
7-Chloro-furo[3,2-b]pyrid...
7-Chloro-furo[3,2-b]pyridine
Furo[3,2-b]pyridine, 7-chloro- | [Molecular Formula]
C7H4ClNO | [MDL Number]
MFCD15143870 | [MOL File]
182691-75-4.mol | [Molecular Weight]
153.57 |
| Chemical Properties | Back Directory | [Boiling point ]
204.3±20.0 °C(Predicted) | [density ]
1.377±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
2.53±0.30(Predicted) | [InChI]
InChI=1S/C7H4ClNO/c8-5-1-3-9-6-2-4-10-7(5)6/h1-4H | [InChIKey]
JVRFEXMVMBMREK-UHFFFAOYSA-N | [SMILES]
C12C=COC1=C(Cl)C=CN=2 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 7-chlorofuro[3,2-b]pyridines from 2-(trimethylsilyl)-7-chlorofuro[3,2-B]pyridines: to a solution of compound 2-(trimethylsilyl)-7-chlorofuro[3,2-B]pyridine (73 g, 0.323 mol, 1.0 eq.) in tetrahydrofuran (THF, 400 mL) was added an aqueous sodium hydroxide solution ( 300 mL, 4 mol/L). The reaction mixture was stirred at 50 °C for 1 h and then cooled to room temperature and 1000 mL of water was added. The mixture was extracted twice with methyl tert-butyl ether (MTBE). The combined organic layers were washed with saturated saline, dried over anhydrous sodium sulfate, concentrated, and recrystallized from a solvent mixture of ethyl acetate and petroleum ether to give 7-chlorofuro[3,2-b]pyridine as an off-white powder (30 g, 60.5% yield).GC-MS analysis showed the molecular ion peak as 153 (EI). | [References]
[1] Patent: WO2018/67422, 2018, A1. Location in patent: Page/Page column 38; 40 |
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| Company Name: |
SPIRO PHARMA
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www.spiropharma.com.cn |
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