| Identification | Back Directory | [Name]
Azide-PEG12-Tos | [CAS]
1821464-56-5 | [Synonyms]
N3-PEG12-Tos
Azide-PEG12-Tos
Azido-PEG12-Tos
2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate | [Molecular Formula]
C31H55N3O14S | [MDL Number]
MFCD29764334 | [MOL File]
1821464-56-5.mol | [Molecular Weight]
725.85 |
| Hazard Information | Back Directory | [Description]
Azide-PEG12-Tos is a monodisperse PEG reagent containing an azide group and a tosyl group. Long PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic reactions. | [Uses]
Azide-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG12-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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