| Identification | Back Directory | [Name]
Propargyl-PEG1-SS-PEG1-PFP ester | [CAS]
1817735-30-0 | [Synonyms]
Propargyl-PEG1-SS-PEG1-PFP ester
Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester | [Molecular Formula]
C16H15F5O4S2 | [MDL Number]
MFCD29042354 | [MOL File]
1817735-30-0.mol | [Molecular Weight]
430.41 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG1-SS-PEG1-PFP ester is a Click Chemistry crosslinker. PFP ester is reactive with amine-bearing molecule. The propargyl groups can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. | [Uses]
Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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