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ChemicalBook--->CAS DataBase List--->181629-93-6

181629-93-6

181629-93-6 Structure

181629-93-6 Structure
IdentificationBack Directory
[Name]

N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
[CAS]

181629-93-6
[Synonyms]

SB 228357
N-[3-fluoro-5-(3-pyridinyl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
N-[3-Fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
1H-Indole-1-carboxamide, N-[3-fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-
[Molecular Formula]

C22H17F4N3O2
[MDL Number]

MFCD00950378
[MOL File]

181629-93-6.mol
[Molecular Weight]

431.38
Chemical PropertiesBack Directory
[Boiling point ]

625.4±55.0 °C(Predicted)
[density ]

1.398±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: ~8 mg/mL, soluble
[form ]

solid
[pka]

9.72±0.70(Predicted)
[color ]

white
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

SB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS).
[Definition]

ChEBI: SB 228357 is an indolyl carboxylic acid.
[Biological Activity]

5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .
[in vivo]

SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy[2].

Animal Model:Male Sprague Dawley rats (200-250?g) injected with Haloperidol[2]
Dosage:0 mg/kg, 0.32 mg/kg, 1 mg/kg, 3.2 mg/kg, 10 mg/kg
Administration: Oral administration; for 90 minutes
Result:Significantly reversed Haloperidol-induced catalepsy.
[IC 50]

5-HT2A Receptor: 6.9 (pKi); 5-HT2C Receptor: 9 (pKi); 5-HT2B Receptor: 8 (pKi)
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE(181629-93-6)1HNMR
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