| Identification | Back Directory | [Name]
JFPVXVDWJQMJEE-QDGUUNGESA-N | [CAS]
1803240-98-3 | [Synonyms]
JFPVXVDWJQMJEE-QDGUUNGESA-N
Cefuroxime D3Q: What is
Cefuroxime D3 Q: What is the CAS Number of
Cefuroxime D3 Q: What is the storage condition of
Cefuroxime D3 Q: What are the applications of
Cefuroxime D3 | [Molecular Formula]
C16H16N4O8S | [MOL File]
1803240-98-3.mol | [Molecular Weight]
424.38 |
| Hazard Information | Back Directory | [Description]
Cefuroxime-d3 is intended for use as an internal standard for the quantification of cefuroxime by GC- or LC-MS. Cefuroxime is a cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria including S. pyogenes, S. pneumoniae, S. viridans, E. coli, P. mirabilis, H. influenzae, and N. gonorrhoeae (mean MICs = 0.005-8.2 μg/ml). Like other cephalosporins, cefuroxime inhibits peptidoglycan crosslinking and bacterial cell wall synthesis. It is resistant to hydrolysis by bacterial β-lactamases, increasing its efficacy against β-lactamase-producing Gram-negative bacteria. Cefuroxime is protective against Gram-positive and Gram-negative infections in vivo with mean ED50 values ranging from 2 to 35 and 1 to 55 mg/kg, in mice and rats, respectively. Formulations containing cefuroxime have been used to treat urinary tract infections. | [Uses]
Cefuroxime-d3 is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria[1]. | [IC 50]
β-lactam | [storage]
Store at -20°C | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Callaghan, et al. Cefuroxime sodium, a New Cephalosporin Antibiotic: Activity in Vitro. Antimicrob Agents Chemother. 1976 Mar;9(3):511-9. DOI:10.1128/AAC.9.3.511
[3] D M Ryan, et al. Cefuroxime sodium, a New Cephalosporin Antibiotic: Activity in Vivo. Antimicrob Agents Chemother. 1976 Mar;9(3):520-5. DOI:10.1128/AAC.9.3.520 |
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