| Identification | Back Directory | [Name]
(Glu20)-Amyloid β-Protein (1-42) | [CAS]
1802086-22-1 | [Synonyms]
(Glu2)-Amyloid β-Protein (1-42)
(Glu20)-Amyloid β-Protein (1-42)
(Glu20)-Amyloid β-Protein (1-42) |
| Hazard Information | Back Directory | [Uses]
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease[1][2]. | [References]
[1] Poduslo JF, et al. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol Dis. 1999 Jun;6(3):190-9. DOI:10.1006/nbdi.1999.0238
[2] Williams TL, et al. The effect of Alzheimer's Aβ aggregation state on the permeation of biomimetic lipid vesicles. Langmuir. 2010 Nov 16;26(22):17260-8. DOI:10.1021/la101581g |
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