| Identification | Back Directory | [Name]
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) amide ammonium salt | [CAS]
1802078-32-5 | [Synonyms]
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) amide ammonium salt | [Molecular Formula]
C68H89N15O26 | [MDL Number]
MFCD19982825 | [MOL File]
1802078-32-5.mol | [Molecular Weight]
1532.54 |
| Chemical Properties | Back Directory | [Boiling point ]
1895.0±65.0 °C(Predicted) | [density ]
1.395±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.20±0.10(Predicted) | [color ]
Light yellow to yellow | [Sequence]
{Mca}-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-{Lys(Dnp)}-NH2 |
| Hazard Information | Back Directory | [Uses]
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1[1]. | [References]
[1] Koike H, et.al. Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells. J Biochem. 1999 Jul;126(1):235-42. DOI:10.1093/oxfordjournals.jbchem.a022428 |
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