| Identification | Back Directory | [Name]
2'-BROMO-4-CHLORO-BIPHENYL | [CAS]
179526-95-5 | [Synonyms]
2-Bromo-4`-chloro-bipheny
2'-BROMO-4-CHLORO-BIPHENYL
2-Bromo-4'-chloro-1'-biphenyl
2-Bromo-4'-chloro-1,1'-biphenyl
1-bromo-2-(4-chlorophenyl)benzene
2-bromo-2-(4-chlorophenyl)benzene
1,1'-Biphenyl, 2-bromo-4'-chloro- | [Molecular Formula]
C12H8BrCl | [MDL Number]
MFCD18072809 | [MOL File]
179526-95-5.mol | [Molecular Weight]
267.549 |
| Chemical Properties | Back Directory | [Melting point ]
41 °C | [Boiling point ]
325.5±17.0 °C(Predicted) | [density ]
1.463 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder to lump | [color ]
White to Orange to Green | [InChI]
InChI=1S/C12H8BrCl/c13-12-4-2-1-3-11(12)9-5-7-10(14)8-6-9/h1-8H | [InChIKey]
WSHZWUXRWQVZQP-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=C(Cl)C=C2)=CC=CC=C1Br |
| Hazard Information | Back Directory | [Chemical Properties]
off-white solid | [Synthesis]
1-Bromo-2-iodobenzene (30 g, 106 mmol) and 4-chlorophenylboronic acid (16.9 g, 108.6 mmol) were added to an aqueous 2M potassium carbonate solution (100 ml) in dioxane solution. Subsequently, tetrakis(triphenylphosphine)palladium (2.45 g, 2 mol%) was added as a catalyst. The reaction mixture was heated and reacted under stirring for 4 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched with potassium carbonate solution followed by separation of the aqueous and organic layers. After the organic layer was concentrated under reduced pressure to remove the solvent, it was purified by column chromatography (eluent: hexane) to afford the target product 2-bromo-4'-chloro-1,1'-biphenyl (A1) as a white solid (25.3 g, 90% yield). | [References]
[1] Patent: KR2017/41159, 2017, A. Location in patent: Paragraph 0274-0276
[2] Organic Letters, 2015, vol. 17, # 2, p. 386 - 389
[3] Organic Letters, 2013, vol. 15, # 24, p. 6186 - 6189
[4] Advanced Synthesis and Catalysis, 2018, vol. 360, # 16, p. 3049 - 3054
[5] Chemical Communications, 2014, vol. 50, # 17, p. 2193 - 2195 |
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