| Identification | Back Directory | [Name]
6-Amino-2-methylphenol | [CAS]
17672-22-9 | [Synonyms]
6- aMinocresol
ASISCHEM D50954
6-AMINO-O-CRESOL
6-AMINO-ORTHO-CRESOL
2-amino-6-methylphenol
2-methyl-6-aminophenol
6-Amino-o-methylphenol
6-Amino-2-methylphenol
6-AMINO-O-CRESOL, 99.5%
phenol, 2-amino-6-methyl-
2-Hydroxy-3-methylaniline
6-Amino-o-cresol AldrichCPR
2-amino-6-methylphenol hydrochlorde
2-amino-6-methylphenol(SALTDATA: HCl) | [EINECS(EC#)]
605-780-1 | [Molecular Formula]
C7H9NO | [MDL Number]
MFCD03788432 | [MOL File]
17672-22-9.mol | [Molecular Weight]
123.15 |
| Chemical Properties | Back Directory | [Appearance]
Appearance:Light yellow crystal powder | [Melting point ]
86℃ | [Boiling point ]
232.9±28.0 °C(Predicted) | [density ]
1.157±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
10.10±0.10(Predicted) | [CAS DataBase Reference]
17672-22-9 |
| Hazard Information | Back Directory | [Chemical Properties]
Appearance:Light yellow crystal powder | [Uses]
6-Amino-2-methylphenol is a colorant that has been classified as a skin sensitizer. It is used in the manufacture of inorganic pigments and other organic compounds, such as dyes and paints. 6-Amino-2-methylphenol absorbs ultraviolet radiation and reacts with chloride to form 2-amino, 6-(chloromethyl) phenol, which has been shown to have subchronic toxicity. This chemical also photodegrades in sunlight, producing free radicals that can damage cells. | [Synthesis]
B. 2-Methyl-6-nitrophenol (542 mg, 3.54 mmol), 10% Pd/C catalyst (54 mg) with EtOAc/EtOH mixed solvent (5.5 mL/11 mL) were placed in a reaction flask and the reaction was stirred overnight under a hydrogen atmosphere and at atmospheric pressure. Upon completion of the reaction, the reaction mixture was filtered through a pad of diatomaceous earth to remove the catalyst and the filtrate was subsequently concentrated under reduced pressure to afford 2-amino-6-methylphenol as a brown solid (373 mg, 85% yield). | [References]
[1] Journal of Organic Chemistry, 2015, vol. 80, # 23, p. 11734 - 11743
[2] Patent: WO2008/110793, 2008, A1. Location in patent: Page/Page column 104
[3] Patent: KR2018/117068, 2018, A. Location in patent: Paragraph 0084; 0625; 0628; 0634; 0635
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 23, p. 7974 - 7985
[5] Journal of the American Chemical Society, 2005, vol. 127, # 30, p. 10545 - 10559 |
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