278789-43-8

176523-95-8

General procedure for the synthesis of ethyl 3-methylpiperidine-3-carboxylate hydrochloride from ethyl 1-Boc-3-methylpiperidine-3-carboxylate: 24.2 g (84.8 mmol) of 1-tert-butyl 3-ethyl 3-methylpiperidine-1,3-dicarboxylate was added to 50 mL of ethyl acetate solution of 2.5 M hydrochloric acid. The reaction mixture was stirred at 20°C for 3 hours, then 100 mL of diethyl ether was added. The precipitated crystals were filtered and washed with diethyl ether to give 16.28 g (97% yield) of ethyl 3-methylpiperidine-3-carboxylate hydrochloride.