| Identification | Back Directory | [Name]
Pixantrone (hydrochloride) | [CAS]
175989-38-5 | [Synonyms]
Pixantrone (hydrochloride)
6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione:hydrochloride | [Molecular Formula]
C17H20ClN5O2 | [MOL File]
175989-38-5.mol | [Molecular Weight]
361.83 |
| Hazard Information | Back Directory | [Uses]
Pixantrone (BBR 2778 (free base)) hydrochloride, a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity[1][2]. | [in vivo]
Pixantrone (i.v., 27 mg/kg, every 7 days, three times) hydrochloride does not worsen pre-existing moderate degenerative cardiomyopathy, causes minimal cardiotoxic in mice following repeated treatment cycles and results in less mortality than mitoxantrone in doxorubicin-pretreated mice[3].
Pixantrone (i.v., 16.25 mg/kg, every week, three times) hydrochloride modulates Lymph node cells (LNC) responses, affacts T cell subpopulations in TAChR-immunized Lewis rats and also shows preventive and therapeutic effect in experimental autoimmune myasthenia gravis (EAMG) rats[4].
| [IC 50]
Topoisomerase II | [References]
[1] Neil Beeharry, et al. Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions. Cancer Biol Ther. 2015;16(9):1397-406. DOI:10.1080/15384047.2015.1070979
[2] Brian B Hasinoff, et al. Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform. J Pharmacol Exp Ther. 2016 Feb;356(2):397-409. DOI:10.1124/jpet.115.228650
[3] Ennio Cavalletti, et al. Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone. Invest New Drugs. 2007 Jun;25(3):187-95. DOI:10.1007/s10637-007-9037-8
[4] Federica Ubiali, et al. Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in Lewis rats. J Immunol. 2008 Feb 15;180(4):2696-703. DOI:10.4049/jimmunol.180.4.2696 |
|
| Company Name: |
ChemShuttle, Inc.
|
| Tel: |
0150-83588313-811 18800520310 |
| Website: |
www.jiehuapharma.com/ |
|