| Identification | Back Directory | [Name]
ethyl 5-hydroxy-2-(phenoxymethyl)-1-benzofuran-3-carboxylate | [CAS]
171506-87-9 | [Synonyms]
T16A(inh)C01
T16A(inh)-C01
T16A(inh) C01
ethyl 5-hydroxy-2-(phenoxymethyl)-1-benzofuran-3-carboxylate | [Molecular Formula]
C18H16O5 | [MDL Number]
MFCD00770219 | [MOL File]
171506-87-9.mol | [Molecular Weight]
312.317 |
| Hazard Information | Back Directory | [Definition]
ChEBI: 5-hydroxy-2-(phenoxymethyl)-3-benzofurancarboxylic acid ethyl ester is a member of benzofurans. | [Biological Activity]
T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01 blocks chloride channel mediated by ANO1 with an IC50 of 8.4 μM, without interfering with calcium signaling[1]. | [References]
[1]. Namkung W, et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21. 286(3):2365-74. |
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