| Identification | Back Directory | [Name]
PNU 96415E | [CAS]
170856-41-4 | [Synonyms]
PNU 96415E
1-[2-(3,4-DIHYDRO-1H-2-BENZOPYRAN-1-YL)ETHYL]-4-(4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE | [Molecular Formula]
C21H26ClFN2O | [MDL Number]
MFCD00940853 | [MOL File]
170856-41-4.mol | [Molecular Weight]
376.9 |
| Hazard Information | Back Directory | [Uses]
PNU 96415E is an antipsychotic agent; SR-2A inhibitor. | [Biological Activity]
Antipsychotic agent. Displays high affinity for dopamine D 4 and serotonergic 5-HT 2A receptors and relatively weak affinity at D 2 receptors (K i values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D 4 , 5-HT 2A , 5-HT 1A , α 1 , D 2 , D 3 , D 1 , α 2 ? and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats. | [in vivo]
PNU-96415E blockes 5-HTP-induced bead twitches in mice and stereotypic behaviours produced by high doses of amphetamine and methylphenidate[1]. | [IC 50]
D4 Receptor; 5-HT2A Receptor | [storage]
Desiccate at RT |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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