| Identification | Back Directory | [Name]
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL | [CAS]
170116-63-9 | [Synonyms]
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
1-Pyrrolidinecarboxylic acid, 2-[[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl]-, phenylmethyl ester, (2S)- | [Molecular Formula]
C20H28N2O5 | [MDL Number]
MFCD00798791 | [MOL File]
170116-63-9.mol | [Molecular Weight]
376.45 |
| Chemical Properties | Back Directory | [Boiling point ]
522.5±50.0 °C(Predicted) | [density ]
1.214±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [pka]
-1.00±0.40(Predicted) | [Sequence]
Pro-{Pro-Aldehyde-dimethyl acetal} |
| Hazard Information | Back Directory | [Uses]
Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2]. | [IC 50]
PREP: 12 nM (IC50) | [References]
[1] Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. DOI:10.1038/417292a
[2] Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial?and?THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. DOI:10.1002/glia.20645 |
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