| Identification | Back Directory | [Name]
YZ129 | [CAS]
1643120-60-8 | [Synonyms]
YZ129
YZ129 4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione | [Molecular Formula]
C19H12N2O2 | [MDL Number]
MFCD31813767 | [MOL File]
1643120-60-8.mol | [Molecular Weight]
300.31 |
| Chemical Properties | Back Directory | [Boiling point ]
543.3±50.0 °C(Predicted) | [density ]
1.411±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 5.6 mg/mL (18.65 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
6.52±0.10(Predicted) | [color ]
Brown to red |
| Hazard Information | Back Directory | [Uses]
YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1]. | [IC 50]
HSP90 | [References]
[1] Liu Z, et al. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8. DOI:10.1016/j.chembiol.2018.11.009 |
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