| Identification | Back Directory | [Name]
ODM-204 | [CAS]
1642818-64-1 | [Synonyms]
ODM-204
Benzonitrile, 4-[[(1R)-3-(1H-imidazol-1-yl)-6,6-dimethyl-2-cyclohexen-1-yl]methylamino]-2-(trifluoromethyl)- | [Molecular Formula]
C20H21F3N4 | [MDL Number]
MFCD31813642 | [MOL File]
1642818-64-1.mol | [Molecular Weight]
374.4 |
| Hazard Information | Back Directory | [Uses]
ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme, with IC50s of 80?nM and 22 nM, respectively. | [IC 50]
CYP17 | [References]
[1] Oksala R, et al. Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1. J Steroid Biochem Mol Biol. 2018 Feb 10. pii: S0960-0760(18)30078-5. DOI:10.1016/j.jsbmb.2018.02.004 |
|
|