| Identification | Back Directory | [Name]
TAPI-0 | [CAS]
163958-73-4 | [Synonyms]
TAPI
TAPI-0 >=95% (HPLC)
N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
L-Alaninamide, N-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl- | [Molecular Formula]
C24H32N4O5 | [MOL File]
163958-73-4.mol | [Molecular Weight]
456.53 |
| Chemical Properties | Back Directory | [density ]
1.227±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
9.17±0.20(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
TAPI 0 is a metalloprotease inhibitor, which inhibits the obligate intracellular human pathogen Chalmydia trachomitis. | [Biochem/physiol Actions]
TAPI-0 is a metalloproteinase inhibitor with selectivity for TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). TAPI-0 also inhibits of collagenase and gelatinase. Although not specific for TACE, TAPI-0 is extensively used to block TACE-mediated TNF-α shedding. | [storage]
Store at -20°C |
|
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Sigma-Aldrich
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Energy Chemical
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Merck KGaA
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