| Identification | Back Directory | [Name]
Bax activator-1 | [CAS]
1638526-94-9 | [Synonyms]
Bax activator-1
Bax activator compound 106
Methanone, [5-[(3,4-dimethylphenyl)methyl]-4,5,6,7-tetrahydro-1-[(3-methoxyphenyl)methyl]-1H-pyrazolo[4,3-c]pyridin-3-yl][(3R)-3-hydroxy-1-piperidinyl]- | [Molecular Formula]
C29H36N4O3 | [MDL Number]
MFCD32062803 | [MOL File]
1638526-94-9.mol | [Molecular Weight]
488.62 |
| Chemical Properties | Back Directory | [Boiling point ]
712.8±60.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.35±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Bax-activator-106 is a specific Bax agonist. It acts by promoting Bax-dependent but not Bak-dependent apoptosis. | [Uses]
Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1]. | [in vivo]
Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice[1]. | Animal Model: | Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)[1] | | Dosage: | 40 mg/kg | | Administration: | Given i.p., each day for 13 days | | Result: | Exhibited anti-tumor activity as a single-agent. |
| [IC 50]
Bax | [References]
[1] Zhao G, et al. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol. 2014 Apr;34(7):1198-207. DOI:10.1128/MCB.00996-13 |
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cjbscvictory
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13348960310 13348960310 |
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https://www.weikeqi-biotech.com/ |
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