| Identification | More | [Name]
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE | [CAS]
163457-23-6 | [Synonyms]
3,3-DIFLUOROPYRROLIDINE HCL
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE | [EINECS(EC#)]
626-850-8 | [Molecular Formula]
C4H8ClF2N | [MDL Number]
MFCD03788948 | [Molecular Weight]
143.56 | [MOL File]
163457-23-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
128-130°C | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
solid | [color ]
White to off white | [Sensitive ]
Hygroscopic | [InChI]
InChI=1S/C4H7F2N.ClH/c5-4(6)1-2-7-3-4;/h7H,1-3H2;1H | [InChIKey]
YYVPZQADFREIFR-UHFFFAOYSA-N | [SMILES]
N1CCC(F)(F)C1.[H]Cl | [CAS DataBase Reference]
163457-23-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT, HYGROSCOPIC | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Beige solid | [Uses]
3,3-Difluoropyrrolidine hydrochloride can be used as a building block in the synthesis of:
- Triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4.
- Dual leucine zipper kinase (DLK) inhibitors.
It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst. |
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