| Identification | Back Directory | [Name]
Carbetocin acetate | [CAS]
1631754-28-3 | [Synonyms]
Carbetocin acetate(37025-55-1 free base) | [Molecular Formula]
C47H73N11O14S | [MDL Number]
MFCD10566502 | [MOL File]
1631754-28-3.mol | [Molecular Weight]
1048.22 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 5 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Carbetocin acetate, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin acetate has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin acetate has the potential for postpartum hemorrhage research. Carbetocin acetate can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS[1][2][3]. | [Biological Activity]
Carbetocin is an oxytocin receptor agonist and a peptide analog of oxytocin .1 It selectively binds to oxytocin receptors over vasopressin V2 receptors (Kds = 1.96 and 61.3 nM, respectively). Carbetocin induces contraction of isolated rat uterine strips (EC50 = 48 nM) and inhibits oxytocin-induced contraction of isolated rat uterine strips (pA2 = 8.21). In vivo, carbetocin (0.35 mg/animal) increases the frequency and amplitude of uterine contractions in early postpartum dairy cows.2 Carbetocin (6.4 mg/kg, i.p.) prevents stress-induced reinstatement of morphine-seeking behavior in mice.3 It also reverses learned helplessness and decreases social withdrawal induced by chronic unpredictable stress in tree shrews.4 Formulations containing carbetocin have been used in the prevention of excessive bleeding after childbirth. | [in vivo]
Carbetocin (2-20 mg/kg; i.p.) acetate has a significant effect of treatment on the percent time spent climbing, swimming and immobile[1].
Carbetocin (1, 10,100 μg/rat, i.c.v.) acetate reveals a dose-dependent increase in the percent time spent swimming following acute administration of 100 μg/rat[1].
| Animal Model: | Male Sprague-Dawley rats weighing between 300 and 500 g[1] | | Dosage: | 2, 6.4, 20 mg/kg | | Administration: | IP; single dose | | Result: | Increased climbing with 6.4 mg/kg and resulted in a significantly greater proportion of time spent swimming with 20 mg/kg.
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| [storage]
-20°C | [References]
1.Engstr?m, T., Barth, T., Melin, P., et al.Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradationEur. J. Pharmacol.355(2-3)203-210(1998)
2.Bajcsy, á.C., Szenci, O., van der Weijden, G.C., et al.The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cowsTheriogenology65(2)400-414(2006)
3.Zanos, P., Georgiou, P., Wright, S.R., et al.The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent miceNeuropsychopharmacology39(4)855-865(2014)
4.Meng, X., Shen, F., Li, C., et al.Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocinPharmacol. Biochem. Behav.1451-8(2016)
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